RNAi modulation of SCAP and therapeutics uses ther

专利名称：RNAi modulation of SCAP and therapeutics

uses thereof

发明人：Juergen Soutschek,Pamela Tan,Jay D.

Horton,Michael S. Brown,Joseph L.Goldstein,Young-Ah Moon

申请号：US11857120申请日：20070918公开号：US07737266B2公开日：20100615

摘要：The invention relates to a double-stranded ribonucleic acid (dsRNA) forinhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisensestrand having a nucleotide sequence which is less that 30 nucleotides in length, generally19-25 nucleotides in length, and which is substantially complementary to at least a partof a SCAP gene. The invention also relates to a pharmaceutical composition comprisingthe dsRNA together with a pharmaceutically acceptable carrier; methods for treatingdiseases caused by Human SCAP expression and the expression of a SCAP gene using thepharmaceutical composition; and methods for inhibiting the expression of a SCAP gene ina cell.

申请人：Juergen Soutschek,Pamela Tan,Jay D. Horton,Michael S. Brown,Joseph L.Goldstein,Young-Ah Moon

地址：Sulgen CH,Kulmbach DE,Plano TX US,Dallas TX US,Dallas TX US,Irving TX US

国籍：CH,DE,US,US,US,US

代理机构：Fulbright & Jaworski, LLP

更多信息请下载全文后查看