Hepatitis A virus vaccines

专利名称：Hepatitis A virus vaccines

发明人：Dina, Dino,Potter, Steven J.,van Nest, Gary

A.,Caput, Daniel

申请号：EP86302465.9申请日：19860403公开号：EP0199480B1公开日：19920701

摘要：The complete genome of the hepatitis A virus (HAV) is disclosed. With the entiregenomic sequence available, epitopes are identified by analogy to known picornavirusessuch as polio virus, synthesized chemically, and conjugated to carrier proteins to provideprotective vaccines against HAV. Alternate methods of preparing vaccines include

preparation of specified peptide sequences using recombinant techniques, preparation ofdeleted virions by modifying the genome to destroy the replicase and LTR regions, andpreparation of particulate immunogenic materials containing an epitope from HAV. Theforegoing alternatives for vaccine preparation are described, and proteins thus preparedused to raise antibodies against HAV.

申请人：CHIRON CORPORATION

地址：4560 HORTON STREET; EMERYVILLE, CALIFORNIA 94608

代理机构：Hallybone, Huw George

更多信息请下载全文后查看