Vectors for tissue-specific replication

专利名称：Vectors for tissue-specific replication发明人：Paul L. Hallenbeck,Yung-Nien Chang,Yawen

L. Chiang

申请号：US10323425申请日：20021219

公开号：US20030113296A1公开日：20030619

摘要：The invention generally relates to targeted gene therapy using recombinantvectors and particularly adenovirus vectors. The invention specifically relates toreplication-conditional vectors and methods for using them. Such vectors are able toselectively replicate in a target tissue to provide a therapeutic benefit from the presenceof the vector per se or from heterologous gene products expressed from the vector anddistributed throughout the tissue. In such vectors, a gene essential for replication isplaced under the control of a heterologous tissue-specific transcriptional regulatorysequence. Thus, replication is conditioned on the presence of a factor(s) that inducestranscription or the absence of a factor(s) that inhibits transcription of the gene by meansof the transcriptional regulatory sequence with this vector; therefore, a target tissue canbe selectively treated.

申请人：HALLENBECK PAUL L.,CHANG YUNG-NIEN,CHIANG YAWEN L.

更多信息请下载全文后查看